Viper toxins affect membrane characteristics of human erythrocytes

Abstract Elucidating electrokinetic stability by which surface charges regulate toxins interaction with erythrocytes is crucial for understanding the cell functionality. Electrokinetic properties of human upon treatment Vipoxin, phospholipase A2 (PLA2) and Vipoxin acidic component (VAC), isolated from Vipera ammodytes meridionalis venom were studied using particle microelectrophoresis. PLA2 treatments alter osmotic fragility erythrocyte membranes. The increased cells viper presented zeta potential before sedimentation during electric field applied preventing aggregation cells. Lipid peroxidation low dose toxin-treated shows reduced LP products compared to untreated apparent proton efflux conductivity assays are performed effectiveness PLA2?>?Vipoxin>VAC discussed. reported results open perspectives a further investigation membrane after shed light on molecular mechanisms driving inflammation neurodegenerative diseases